Multiple Myeloma
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ALLG MM23 SeaLAND (ND MM)
An ALLG phase 3 randomised trial of Selinexor and Lenalidomide versus lenalidomide maintenance post Autologous stem cell transplant for patients with Newly Diagnosed multiple myeloma
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Newly Diagnosed
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GSK2857916 DREAMM 9 (209664) (ND MM)
A Phase 3, Randomized, Open-Label Study of Belantamab Mafodotin Administered in Combination with Bortezomib, Lenalidomide and Dexamethasone Versus Bortezomib, Lenalidomide and Dexamethasone Alone in Participants with Newly Diagnosed Multiple Myeloma who are Ineligible for Autologous Stem Cell Transplantation
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Pfizer MAGNETISMM-6 (ND MM)
AN OPEN-LABEL, 2-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) + DARATUMUMAB + LENALIDOMIDE VERSUS
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Pfizer MAGNETISMM-7 (ND MM)
A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATION
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ALLG MM26 NORM
Novel Combinations for Orphan Myeloma: The NORM Platform Study
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Abbvie M21-406 (R/R MM)
First In Human Study of the BCL-2 Inhibitor ABBV-453 in Biomarker Selected Subjects with Relapsed or Refractory Multiple Myeloma.
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Abbvie M22-947 (R/R MM)
A Dose Escalation and Expansion Study of ABBV-383 in Combination with Anti-Cancer Regimens for the Treatment of Patients with Relapsed/Refractory Multiple Myeloma
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ALLG MM25 Viber-M (R/R MM)
A phase Ib/II study of Venetoclax, Iberdomide and Dexamethasone for patients in first or second relapse of Multiple Myeloma with t(11;14)
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AMaRC 20-01 IBIS ( R/R MM)
An immuno-therapeutic salvage strategy for ‘functional’ high-risk (FHR) multiple myeloma incorporating Iberdomide, Isatuximab and Dexamethasone (IBIS)
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Relapsed/
Refractory
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AMaRC 19-02 BelaCarD (R/R MM)
A phase I/II single arm study of combination Belantamab Mafodotin, Carfilzomib, Dexamethasone in patients with early relapsed multiple myeloma.
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BGB-11417-105 (R/R MM)
A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417 in Combination With Dexamethasone and Carfilzomib/Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)
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BMS CA057-001 Successor -1 (R/R MM)
A phase 3, two- stage randomised multicentre open label study comparing CC-92480, Bortezomib and dexamethasone (480Vd) Vs Pomalidomide, Bortezomib and dexamethasone (PVd) in subjects with relapsed or refractory multiple myeloma (RRMM)
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BMS CA057-008 Successor -2 (R/R MM)
A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing CC-92480
(BMS-986348), Carfilzomib, and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants with Relapsed or Refractory Multiple Myeloma (RRMM)
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CC-220-MM-002 EXCALIBER (R/R MM)
A Phase 3, Randomized, Multicenter, Open-Label Study Comparing Iberdomide, Daratumumab And Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, And Dexamethasone (Dvd) In Subjects With Relapsed Or Refractory Multiple Myeloma
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Genetech GO43227 (CAMMA 3) R/R MM)
A Phase 1b, Open Label, Multicentre, Trial evaluating the safety, pharmacokinetics, and activity of subcutaneous cevostaman (BFCR4350A) in patients with replapsed or refractory multiple myelomas (CAMMA3)
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GSK 208887 DREAMM 5 (R/R MM)
A Phase I/II, Randomized, Open-label Platform Study Utilizing a Master Protocol to Study Belantamab Mafodotin (GSK2857916) in Combination with Anti- Cancer Treatments in Participants with Relapsed/Refractory Multiple Myeloma
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GSK 218670 DREAMM20 (R/R MM)
A Phase 1/2 open-label, multicentre, dose escalation and expansion study to investigate the safety, tolerability, and clinical activity of belantamab as monotherapy and in combination with other treatments in participants with multiple myeloma.
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IBS 2001-101 (R/R MM)
A Phase 1, First-in-Human, Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study of Single-Agent ISB 2001 in Subjects with Relapsed/Refractory Multiple Myeloma
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Janssen MajesTEC-9 (R/R MM)
A Phase 3 Randomized Study Comparing Teclistamab Monotherapy versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants with Relapsed or Refractory Multiple Myeloma who have Received 1 to 3 Prior Lines of Therapy, Including an Anti-CD38 Monoclonal Antibody and Lenalidomide
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Janssen MonumenTAL-2 (R/R MM)
A Multi-arm Phase 1b Study of Talquetamab with Other Anticancer Therapies in Participants with Multiple Myeloma
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Janssen RedirecT-1 (R/R MM)
A Phase 1b/2 Dose Escalation and Expansion Study of the Combination of the Bispecific T Cell Redirection Antibodies Talquetamab and Teclistamab in Participants with Relapsed or Refractory Multiple Myeloma
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Novotech ICHNOS ISB 1442-101 (R/R MM)
A Phase 1/2, First-in-Human, Multicenter, Open-Label, Dose Escalation and Dose-Expansion Study of Single-Agent ISB 1442 in Patients with Relapsed/Refractory Multiple Myeloma
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Novotech ISB 2001-101 (R/R MM)
A Phase 1, First-in-Human, Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study of Single-Agent ISB 2001 in Subjects with Relapsed/Refractory Multiple Myeloma.
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Pfizer MAGNETISMM-5 (R/R MM)
An open-label, 3-arm, Multicenter, Randomized Phase 3 Study to Evaluate the efficacy and safety of Elranatamab (pf-06863135) Monotherapy and Elranatamab + Daratumumab versus Daratumumab + Pomalidomide + Dexamethasone in participants with Relapsed/Refractory Multiple Myeloma who have received at least 1 prior line of therapy including Lenalidomide and a proteasome inhibitor.
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Regeneron (R/R MM)
AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF LINVOSELTAMAB (REGN5458; ANTI-BCMA X ANTI-CD3 BISPECIFIC ANTIBODY) VERSUS THE COMBINATION OF ELOTUZUMAB, POMALIDOMIDE, AND DEXAMETHASONE (EPd), IN PATIENTS WITH
RELAPSED/REFRACTORY MULTIPLE MYELOMA (LINKER-MM3)
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Roche CO43476 (CAMMA-2)
A phase 1/11, open-label, multi-cohort study to evaluate the efficacy and safety of cevostamab in prior b cell maturation antigen-exposed patients with relapsed/refractory multiple myeloma
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Roche CO43923 Platform Study (Plycom)
A PLATFORM STUDY EVALUATING THE SAFETY AND EFFICACY OF MULTIPLE TREATMENTS IN PATIENTS WITH MULTIPLE MYELOMA
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SANOFI ACT16482 UMBRELLA (R/R MM)
Phase 1-2 UMBRELLA trial evaluating isatuximab with or without dexamethasone in combination with novel agents compared to isatuximab with pomalidomide and dexamethasone in relapsed or refractory multiple myeloma (RRMM)
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Sanofi EFC15951 Iraklia (R/RMM)
A randomized, Phase 3, open label study evaluating subcutaneous versus intravenous administration of isatuximab in combination with pomalidomide and dexamethasone in adult patients with relapsed and/or refractory multiple myeloma (RRMM)
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Sanofi ACT17453 Izalco (R/RMM)
A randomized, Phase 2, open label study evaluating subcutaneous administration of isatuximab in combination with carfilzomib and dexamethasone in adult participants with relapsed and/or refractory multiple myeloma (RRMM)
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Acute Myeloid Leukaemia & Myelodysplastic Syndrome
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Newly diagnosed
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ALLG AML M23 (HOVON) (TN AML, TN MDS)
A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy.
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ALLG AML M25 (INTERVENE) (ND AML)
An ALLG Phase 2 study to Investigate Novel Triplets to Extend Remission with VENetoclax in Elderly (INTERVENE) Acute Myeloid Leukaemia
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KER050-MD-201 (ND MDS)
A Phase 2, Open-Label, Ascending Dose Study of KER-050 for the Treatment of Anemia in Patients with Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)
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Relapsed Refractory
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APTOSE HM-FLT-101 (R/R AML)
A Phase 1/2, Open-label, Multicenter, Dose Escalation and Expansion Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HM43239 in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)
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BGB-11417-103 (R/R Myeloid Malignancies)
A Phase 1b/2, Open-Label, Dose Finding, and Expansion Study of the Bcl-2 Inhibitor BGB-11417 in Patients With Myeloid Malignancies
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BMS CA059-001 (R/R AML MDS)
A phase 1, open-label, dose finding study of CC-95251 alone and in combination with Antineoplastic agents in subjects with Acute Myeloid Leukemia and Myelodysplastic syndromes
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Myelofibrosis
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Relapsed Refractory
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Pharmaxis (R/R MF)
A phase 1/2a study to evaluate safety, pharmacokinetic and pharmacodynamic dose escalation and expansion study of PXS-5505 in patients with primary, post-polycythemia vera or post-essential thrombocythemia myelofibrosis
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Relapsed Refractory
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KER050-MF-301 (R/R MF)
A Phase 2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KER-050 as Monotherapy or in Combination with Ruxolitinib in Participants with Myelofibrosis
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Chronic Lymphocytic Leukaemia
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Treatment Naïve & Relapsed Refractory
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BGB-11417-101 (TN, R/R CLL)
A Phase 1/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417 in Patients with Mature B-Cell Malignancies
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Relapsed Refractory
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LOXO-BTK-20022 (R/R CLL)
Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) plus Venetoclax and Rituximab versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-322)
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PCYC-1145-LT (R/R CLL)
Extended treatment protocol for subjects continuing to benefit from ibrutinib after completion of ibrutinib clinical trials
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BGB-16673-101 (RR CLL)
A Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies
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AbbVIE- M22-716 (B Cell)
A First-In-Human Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-319 in B-cell Malignancies
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Waldenström Macroglobulinemia
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Treatment Naïve &
Relapsed Refractory
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BGB-11417-101 (B Cell)
A Phase 1/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417 in Patients with Mature B-Cell Malignancies
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BGB- 16673-101 (RR B-Cell Malignancies)
Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies
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Lymphomas
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AbbVIE- M22-716 (B Cell)
A First-In-Human Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-319 in B-cell Malignancies
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Treatment Naïve &
Relapsed Refractory
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ALLG NHL30 PETReA (TN FL)
Phase 3 evaluation of PET-guided, Response-Adapted therapy in patients with previously untreated, high tumour burden follicular lymphoma
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BGB-11417-101 (R/R) B-cell NHL
A Phase 1/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417 in Patients with Mature B-Cell Malignancies
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BGB- 16673-101 (RR B-Cell Malignancies)
Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies
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BGB-3111-308 (RR MZL/FL)
A Phase 3 Randomized, Open-Label, Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
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GENMAB GCT3013-01 (R/R DLBCL and FL)
A Phase 1/2, Open-Label, Dose-Escalation Trial of GEN3013 in Patients with Relapsed, Progressive or Refractory B-Cell Lymphoma
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MERCK (MK-4280-003) (R/R HL, DLBCL, NHL)
A Phase 1/Phase 2 Clinical Study to Evaluate the Safety and Efficacy of a Combination of MK-4280 and Pembrolizumab (MK-3475) in Participants with Hematologic Malignancies
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Bleeding Disorders
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DIAAMOND (Aplastic Anaemia)
Section A: Avatrombopag plus up Front ImmunosuppReSsive Therapy in treatment-naive severe aplastic anaemia - The DIAAMOND Ava-FIRST Trial
Section B: Avatrombopag iN Relapsed or Refractory severe aplastic anaemia as EXtra Therapy – The DIAAMOND Ava-NEXT Trial
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Registries / Other
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Myeloma 1000 Registry
The Myeloma 1000 Project
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MRDR Registry
Myeloma & Related Diseases Registry
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NBCR
Australasian Leukaemia and Lymphoma Group National Blood Cancer Registry (previously known as AMLM18)
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LaRDR (Lymphoma and Related Disease Registry)
Lymphoma and Related Diseases Registry (LaRDR)
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